MLD Family Conference™ ... Tarrytown, New York - 2016
Contact Dean Suhr <deansuhr@MLDfoundation.org> +1 503-656-4808, USA: 1-800-617-8387, or FAX +1 503-212-0159
|This conference is organized by the MLD Foundation. Check with your tax advisor about the deductibility of any expenses associated with this conference.|
Prior to joining Shire, he was an Associate Professor of Pediatrics and Neurology at University of Minnesota, working on the treatment of Adrenoleukodystrophy and other lysosomal leukodystrophies with Hematopoietic Cell Transplant. Prior to joining the faculty at University of Minnesota, he had developed expertise in a number of other rare, pediatric genetic diseases including cystinosis, osteogenesis imperfecta and the Oculocerebrorenal syndrome of Lowe.
He received his B.A. in Chemistry (Cornell University, Ithaca, NY), an MD and PhD - Genetics ( University of Pennsylvania, Philadelphia, PA) and clinical training in Adult Neurology (Johns Hopkins Hospital, Baltimore, MD), Medical and Biochemical Genetics (NICHD, Bethesda, MD), and Pediatric Neurology (University of Minnesota).
He has co-authored many peer reviewed articles, and serves on the Medical and Scientific Advisory Boards of the MLD Foundation and Lowe Syndrome Association.
Dr. Wenger directs the largest lysosomal storage diseases (LSD) testing laboratory in the world at Jefferson University in Philadelphia. MLD Foundation considers his work to be the gold standard of consistency and quality for MLD and other lysosomal disease (LSD) diagnostics.
Dr. Wenger is a member of the MLD Foundation Medical and Scientific Advisory Board.
The LSDs are a group of genetic disorders cause by mutations in genes that code for proteins required for the lysosomal catabolism of naturally occurring carbohydrates, proteins, and lipids. About 35 such disorders have been defined and over 20 are diagnosed in this laboratory. Samples are sent to this laboratory from around the world for help in diagnosing a patient with certain symptoms, for carrier testing and for prenatal testing. Most diagnostic tests are enzyme-based but others require the use of specific antibodies, tissue extraction, radio-labelled lipid loading or molecular analysis for known mutations. The experience of the research laboratory is brought to diagnostic laboratory in the form of new test development, and interesting patients can be studied in the research laboratory to help answer important questions regarding protein structure and function.
BS, Temple University - School of Pharmacy, Pharmacy - 1964
PhD, Temple University - School of Medicine, Biochemistry - 1968
American College of Medical Genetics, American Board of Medical Genetics, Board Certification, Clinical Biochemical Genetics and Clinical Molecular Genetics
Research and Clinical Interests
Krabbe disease ... Dr. Wenger's laboratory the first laboratory to purify GALC and clone the GALC cDNA and gene which causes KD. The lab has diagnosed nearly 400 patients of all ages with KD spanning nearly 60 mutations. Dr. Wenger has placed human and mouse cDNAs into several viral vectors including retroviral, adeno-associated viruses, lentivirus and SV40. They have successfully transduced oligodendrocytes from the twitcher mice model with viral vectors containing human GALC cDNA and corrected them to a normal phenotype.
ACADEMIC APPOINTMENTS (1997-present):
Jefferson Medical College, Philadelphia, PA. September 1986 - November 1998, Professor of Medicine (Medical Genetics), and Biochemistry and Molecular Pharmacology
Director, Lysosomal Diseases Testing Laboratory. 1974-present
OTHER ACTIVITIES (1997-present)
Scientific Advisory Committee of the National Tay-Sachs and Allied Diseases Association
Advisor - United Leukodystrophy Foundation, Inc.
Editorial Board of Molecular Genetics and Metabolism (1991-present)
Medical and Scientific Advisory Board - MLD Foundation
Scientific Advisory Board of the National Mucopolysaccharidosis Society
Scientific/Medical Advisory Committee of the Canavan Disease Foundation
Program Committee-American Society of Human Genetics (1994-1997)
NIH Board of Scientific Counselors; review of Intramural Research Programs at NIH, October 1997
Working Group of NIGMS Human Genetic Cell Repository, 2001-2004